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  Social anxiety disorder (SAD) is a prevalent and often debilitating psychiatric disorder that can assume a chronic course even when treated. Despite the identification of evidence-based pharmacological and behavioral treatments for SAD, much room for improved outcomes exists and 3,4-methylenedioxymethamphetamine (MDMA) has been proposed as a promising adjunctive treatment to psychological interventions for disorders...

  Despite decades of medical research for what remains a substantial public health problem, there are no medications approved by the U.S. Food and Drug Administration for the treatment of cocaine use disorder. Standard behavioral treatments, meanwhile, are beset by high failure rates. A line of pharmacotherapy research that holds promise is modulation of glutamate...

As you prepare to enjoy your magic mushroom trip, we recommend for you to watch exciting and interesting movies to enhance your experience during your mushroom trips. The movies on the following list are amazing movies that are certainly going to make your psychedelic trips memorable as they are fun to watch, filled with bright...

    Major depression is a commonly occurring disorder associated with high morbidity, socio-economic burden, and rates of completed suicide (1, 2). It affects 10–15% of the general population and has been ranked by The World Health Organization (WHO) as the fourth leading contributor to the global burden of disease (5), with a forecast of...

    The success of modern medicine creates a growing population of those suffering from life-threatening illnesses (LTI) who often experience anxiety, depression, and existential distress. We present a novel approach, investigating MDMA-assisted psychotherapy for the treatment of anxiety in people with an LTI. Participants with anxiety from an LTI were randomized in a double-blind...

    Ketamine is a dissociative anaesthetic drug which acts on the central nervous system chiefly through antagonism of the n-methyl-d-aspartate (NMDA) receptor. Recently, ketamine has attracted attention as a rapid-acting anti-depressant, but other studies have also reported its efficacy in reducing problematic alcohol and drug use. This review explores the preclinical and clinical research into ketamine’s ability...

    This article involves addressing the neurobiological mechanisms of psychedelic drugs, the resulting changes in brain activity and integration of traditional viewpoints. Science is still at the early stages of understanding psychedelic molecular mechanisms and even further from understanding the psychedelic state as any scientist who has experienced it is aware.   Current Classification...

            Stroke and traumatic brain injury (TBI) are among the leading causes of disability. Even after engaging in rehabilitation, nearly half of patients with severe TBI requiring hospitalization are left with major disability. Despite decades of investigation, pharmacologic treatment of brain injury is still a field in its infancy.  ...

    From the beginning of therapeutic research with psychedelics, music listening has been consistently used as a method to guide or support therapeutic experiences during the acute effects of psychedelic drugs. Recent findings point to the potential of music to support meaning-making, emotionality, and mental imagery after the administration of psychedelics, and suggest that...

    Psilocybin-occasioned mystical experiences have been linked to persisting effects in healthy volunteers including positive changes in behavior, attitudes, and values, and increases in the personality domain of openness. In an open-label pilot-study of psilocybin-facilitated smoking addiction treatment, 15 smokers received 2 or 3 doses of psilocybin in the context of cognitive behavioral therapy...